![]() Subsequent analysis of the effect of low concentration benzene exposure on genetic damage found significantly increased MN frequency increased compared with the control group ( P < 0.05). The meta-analysis results showed that occupational benzene exposure led to significantly increased Micronucleus (MN) frequency, Sister chromatid exchange (SCE) frequency, Chromosome aberration (CA) frequency, Olive Tail moment (OTM), Tail moment (TM), Tail length (TL), and Tail DNA% (T DNA%) compared to the control group ( P < 0.05), and the pooled effect value estimates were 1.36, 0.98, 0.76, 1.06, 0.96, 1.78, and 1.42, respectively. ResultsĪ total of 68 eligible articles were finally included for the synthetic analyses. ![]() We utilized Stata 12.0 software to perform the meta-analysis in the present study. The imported articles were managed by Endnote X7, and the data were extracted and sorted by Excel 2013. Two researchers independently extracted and evaluated the data according to the inclusion and exclusion criteria of the literature. We conducted a search of five databases, including Pub Med, Web of Science, China National Knowledge Infrastructure (CNKI), Wan Fang Data and Chongqing VIP, to identify relevant articles up to December 25, 2018. So we conducted a meta-analysis, and to explore the influence of low concentration benzene exposure on workers’ genetic damage indicators using 3.25 mg/m 3 as the boundary value, in order to provide a basis for improved prevention and control of the harm from benzene exposure to the occupational population. Although the links between benzene and various types of genetic damage indicators have been evaluated in several studies, but their results remain inconsistent. Meanwhile, benzene is a human carcinogen leading to leukemia. ![]() ![]() Benzene, an important component of organic solvents, is commonly used in industry. ![]()
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